GABRB3 Antikörper (pSer408, pSer409)
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- Target Alle GABRB3 Antikörper anzeigen
- GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
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Bindungsspezifität
- pSer408, pSer409
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Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Hund, Huhn, Zebrafisch (Danio rerio), Non-Human Primate, Xenopus laevis
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GABRB3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody has been directly tested for reactivity in Western blots with rat tissue. Specific for the ~53k GABAA receptor beta-3 subunit phosphorylated at Ser408/409. Immunolabeling of the GABAA band is completely blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, non-Human primates, Xenopus and Zebrafish.
Species reactivity (tested):Rat. - Aufreinigung
- Affinity Chromatography.
- Immunogen
- Phosphopeptide corresponding to amino acid residues surrounding the di-phospho- Ser408/409 of the Rat GABAA receptor, beta-3 subunit.
- Isotyp
- IgG
- Top Product
- Discover our top product GABRB3 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody undiluted (in aliquots) at -20 °C.
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- Target
- GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
- Andere Bezeichnung
- GABRB3 (GABRB3 Produkte)
- Synonyme
- GABRB3 antikoerper, eca5 antikoerper, LOC100230475 antikoerper, ECA5 antikoerper, A230092K12Rik antikoerper, AW049585 antikoerper, Cp1 antikoerper, Gabrb-3 antikoerper, beta3 antikoerper, gamma-aminobutyric acid type A receptor beta3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, beta 3 antikoerper, gamma-aminobutyric acid type A receptor beta 3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 antikoerper, GABRB3 antikoerper, gabrb3 antikoerper, Gabrb3 antikoerper
- Hintergrund
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. Phosphorylation of Serine 408 and Serine 409 within the Beta-3 subunit have been shown to be critical for the functional modulation of Beta-3 containing recombinant receptors (Brandon et al., 2000).Synonyms: GABA A receptor subunit beta-3, GABRB-3, Gamma-aminobutyric acid receptor subunit beta-3
- Gen-ID
- 24922
- NCBI Accession
- NP_058761
- Pathways
- Sensory Perception of Sound
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