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RUSC1 Antikörper (C-Term)

RUSC1 Reaktivität: Human, Maus, Ratte WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500648
  • Target Alle RUSC1 Antikörper anzeigen
    RUSC1 (RUN and SH3 Domain Containing 1 (RUSC1))
    Bindungsspezifität
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 25
    • 2
    Kaninchen
    Klonalität
    • 27
    Polyklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RUSC1 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 13
    • 13
    • 10
    • 5
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects NESCA.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    RUSC1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human RUSC1.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    RUSC1 (RUN and SH3 Domain Containing 1 (RUSC1))
    Andere Bezeichnung
    NESCA (RUSC1 Produkte)
    Synonyme
    NESCA antikoerper, 2210403N08Rik antikoerper, AA408288 antikoerper, RUN and SH3 domain containing 1 antikoerper, RUSC1 antikoerper, Rusc1 antikoerper
    Hintergrund
    RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30 % amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IkappaB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-kappaB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-kappaB activation pathway.Synonyms: RUN and SH3 domain-containing protein 1, RUSC1
    Gen-ID
    23623
    NCBI Accession
    NP_001098673
    UniProt
    Q9BVN2
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