23kDa antikoerper, AA408749 antikoerper, SNAP-23 antikoerper, Sndt antikoerper, Syndet antikoerper, HsT17016 antikoerper, SNAP23A antikoerper, SNAP23B antikoerper, XOSNAP-23 antikoerper, snap23-A antikoerper, synaptosome associated protein 23 antikoerper, synaptosome associated protein 23kDa antikoerper, synaptosomal-associated protein 23 antikoerper, synaptosome associated protein 23kDa L homeolog antikoerper, SNAP23 antikoerper, snap23 antikoerper, Snap23 antikoerper, snap23.L antikoerper
Hintergrund
Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.Synonyms: SNAP-23, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23