PTGS1 Antikörper (C-Term)

Produktnummer ABIN374151

Produktdetails anti-PTGS1 Antikörper

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PTGS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: C-QDDGPAVERP STEL

Spezifität: This antibody is expected to recognize both Human isoforms of COX1 according to NP_000953.2 and NP_542158.1.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence Genename: PTGS1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 32000. Western blot: 1 - 3 μg/mL. Approx 65-70 kDa bands seen in HeLa lysate. Immunohistochemistry on paraffin sections: 3 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PTGS1

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Andere Bezeichnung: Cyclooxygenase 1 (PTGS1 Produkte)

Synonyme: COX-1 antikoerper, cox-1 antikoerper, PTGS1 antikoerper, Ptgs1 antikoerper, COX1 antikoerper, Cox-1 antikoerper, Cox-3 antikoerper, PGHS-1 antikoerper, PHS 1 antikoerper, Pghs1 antikoerper, Cox1 antikoerper, Cox3 antikoerper, cox1 antikoerper, zCOX-1 antikoerper, COX3 antikoerper, PCOX1 antikoerper, PES-1 antikoerper, PGG/HS antikoerper, PGHS1 antikoerper, PHS1 antikoerper, PTGHS antikoerper, COX-3 antikoerper, prostaglandin-endoperoxide synthase 1 antikoerper, cyclooxygenase-1 antikoerper, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antikoerper, prostaglandin-endoperoxide synthase 1 S homeolog antikoerper, PTGS1 antikoerper, cox-1 antikoerper, Ptgs1 antikoerper, ptgs1 antikoerper, ptgs1.S antikoerper

Hintergrund: Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX2.Synonyms: COX-1, COX1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PTGS1, Prostaglandin G/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1

Molekulargewicht: 64.5kDa (NP_542158.1) and 68.7kDa (NP_000953.2)

Gen-ID: 5742

NCBI Accession: NP_000953

UniProt: P23219