ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) (AA 262-277) Antikörper

Details zu Produkt Nr. ABIN5551799, Anbieter: Anmelden zum Anzeigen
Antigen
  • MDR1
  • xemdr
  • ABC20
  • CD243
  • CLCS
  • GP170
  • P-GP
  • PGY1
  • p-gp
  • Abcb1
  • Mdr1a
  • ABCB1
  • PGP1
  • Mdr1
  • Mdr1b
  • Pgy-1
  • Pgy1
  • mdr
  • Mdr
  • Cd243
  • Mdr-1
  • Mod-2
  • Mod-2r
  • Mod-2s
  • Mod2-r
  • Mod2-s
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B
  • malic enzyme complex, mitochondrial
  • ABCB1
  • abcb1
  • Abcb1a
  • Abcb1b
  • Mod2
Epitop
AA 262-277
38
36
13
9
7
4
3
3
3
2
2
2
2
2
1
1
1
1
1
Reaktivität
Hund, Human, Affe, Maus, Ratte (Rattus)
268
27
17
13
10
7
7
2
2
1
1
1
1
1
1
1
1
1
Wirt
Kaninchen
182
97
Klonalität
Polyklonal
Konjugat
Unkonjugiert
14
9
9
7
5
5
4
4
4
4
4
4
4
4
4
3
2
2
2
2
2
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
140
82
75
74
37
35
24
23
8
7
6
3
3
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Synthetic peptide corresponding to amino acids 262-277 of Human ABCB1 protein.
Isotyp IgG
Spezifität This antibody is directed against Human ABCB1 protein.
Kreuzreaktivität (Details) Species reactivity (expected):Monkey, Canine, Mouse and Rat.
Species reactivity (tested):Human.
Produktmerkmale Concentration: 1.28 mg/mL (by UV absorbance at 280 nm)
Reinigung Immunoaffinity Chromatography.
Andere Bezeichnung CD243 / MDR1 (ABCB1 Antibody Abstract)
Hintergrund ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.Synonyms: ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, PGY1
Gen-ID 5243
NCBI Accession NP_000918
UniProt P08183
Applikationshinweise ELISA: 1/10,000-1/50,000. Western Blot: 1/200-1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.28 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide as preservative.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to to immediate use.
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