SMAD5 Antikörper (SMAD, Mothers Against DPP Homolog 5) (C-Term)

Details for Product anti-SMAD5 Antibody No. ABIN5542809, Anbieter: Anmelden zum Anzeigen
Antigen
  • SBN
  • fb67b04
  • mad
  • madh5
  • sb:cb400
  • smd5
  • wu:fb67b04
  • XSmad4alpha
  • dpc4
  • jip
  • jv5-1
  • madh4
  • smad10
  • smad5
  • xsmad4
  • DWFC
  • JV5-1
  • MADH5
  • 1110051M15Rik
  • AI451355
  • Dwf-C
  • Madh5
  • MusMLP
  • SMAD5
  • DKFZp468M0619
  • SMAD family member 5
  • MAD homolog 5 (Drosophila)
  • SMAD family member 4, gene 2
  • SMAD5
  • smad5
  • smad4.2-b
  • Smad5
Epitop
C-Term
20
16
11
10
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
105
47
38
8
7
6
6
5
5
4
3
2
2
1
Wirt
Maus
68
38
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser SMAD5 Antikörper ist unkonjugiert
3
3
3
3
3
3
Applikation
Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
102
57
28
25
18
17
10
3
2
1
1
1
1
Optionen
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Immunogen Purified recombinant human SMAD5 (C-terminus) protein fragments expressed in E.coli.
Klon 4B10-B10-B6
Isotyp IgG1
Spezifität This antibody detects endogenous levels of SMAD5 (C-terminus) .
Kreuzreaktivität (Details) Does not cross-react with related proteins.
Reinigung Affinity purified
Andere Bezeichnung SMAD5 (SMAD5 Antibody Abstract)
Hintergrund SMAD5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. It is a receptor-regulated SMAD (R-SMAD), and acts as an intracellular signal transducer for the transforming growth factor beta superfamily. SMAD5 is activated through serine phosphorylation by BMP (bone morphogenetic proteins) type 1 receptor kinase. It is cytoplasmic in the absence of its ligand and migrates into the nucleus upon phosphorylation and complex formation with SMAD4. Here the SMAD5/SMAD4 complex stimulates the transcription of target genes.
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Subunit structure: May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1.
Subcellular location: Cytoplasm. Nucleus
Sequence similarities: Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain
Molekulargewicht 60 kDa
Gen-ID 4090
NCBI Accession NM_001001420
UniProt Q99717
Forschungsgebiet Signaling, Transcription Factors, Organogenesis
Applikationshinweise WB Dilution: 1:1000
ICC Dilution: 1:75
FACS Dilution: 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer 0.1 M Tris-Glycine ( pH 7.4, 150 mM NaCl) with 0.2 % sodium azide, 50 % glycerol
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C