IL13 Receptor alpha 1 Antikörper (Extracellular Domain)

Produktnummer ABIN5540413

Produktdetails anti-IL13 Receptor alpha 1 Antikörper

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Bindungsspezifität: Extracellular Domain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL13 Receptor alpha 1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Spezifität: Clone GM1C8 recognises IL-13Rα1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (W. Luttmann, unpublished data). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells. Species: Human.

Aufreinigung: Protein G chromatography

Immunogen: cDNA of the human IL-13Ralpha1 chain extracellular domain (U62858).

Klon: GM1C8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 μg/10 6 cells. The antibody is routinely tested by on BOSC cells transiently transfected with an IL-13Rα1 expression vector. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. It is expected that the antibody will be suited for all applications where recognition of the native protein is required.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.2 Preservatives: 0.01 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Referenzen für anti-IL13 Receptor alpha 1 Antikörper (ABIN5540413)

Bizzarro, Fontanella, Carratù, Belvedere, Marfella, Parente, Petrella: "Annexin A1 N-terminal derived peptide Ac2-26 stimulates fibroblast migration in high glucose conditions." in: PLoS ONE, Vol. 7, Issue 9, pp. e45639, (2013) (PubMed).

Thomas, Zhu, Schnaar, Alves, Konstantopoulos: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, (2008) (PubMed).

Kunii, Nemoto, Kanaya, Tsubahara, Shimauchi: "Expression of CD13/aminopeptidase N on human gingival fibroblasts and up-regulation upon stimulation with interleukin-4 and interleukin-13." in: Journal of periodontal research, Vol. 40, Issue 2, pp. 138-46, (2005) (PubMed).

Bade, Lohrmann, ten Brinke, Wolbink, Wolbink, ten Berge, Virchow, Luttmann, Hack: "Detection of soluble human granzyme K in vitro and in vivo." in: European journal of immunology, Vol. 35, Issue 10, pp. 2940-8, (2005) (PubMed).

Details zu IL13 Receptor alpha 1

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Andere Bezeichnung: cd213a1,il13ra1 (IL13RA1 Produkte)

Synonyme: CD213A2 antikoerper, CT19 antikoerper, IL-13R antikoerper, IL13BP antikoerper, CD213A1 antikoerper, IL-13Ra antikoerper, NR4 antikoerper, AI882074 antikoerper, CD213a1 antikoerper, IL-13r[a] antikoerper, Il13ra antikoerper, IL13RA1 antikoerper, il-13ra1 antikoerper, si:ch211-150g2.2 antikoerper, interleukin 13 receptor subunit alpha 2 antikoerper, interleukin 13 receptor subunit alpha 1 antikoerper, interleukin 13 receptor, alpha 1 antikoerper, interleukin 13 receptor, alpha 1-like antikoerper, IL13RA2 antikoerper, IL13RA1 antikoerper, Il13ra1 antikoerper, il13ra1 antikoerper, LOC100360218 antikoerper

Hintergrund: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.

UniProt: P78552

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response