GLI2 Antikörper (Middle Region)

Produktnummer ABIN5516755

Produktdetails anti-GLI2 Antikörper

Target: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: RNDVHLRTPL LKENGDSEAG TEPGGPESTE ASSTSQAVED CLHVRAIKTE

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GLI2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GLI2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-GLI2 Antikörper (ABIN5516755)

Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: "Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy." in: PLoS ONE, Vol. 11, Issue 12, pp. e0167665, (2016) (PubMed).

Details zu GLI2

Target: GLI2 (GLI Family Zinc Finger 2 (GLI2))

Andere Bezeichnung: GLI2 (GLI2 Produkte)

Synonyme: HPE9 antikoerper, THP1 antikoerper, THP2 antikoerper, GLI2/GLI4 antikoerper, GLI3 antikoerper, AW546128 antikoerper, GLI family zinc finger 2 antikoerper, GLI-Kruppel family member GLI2 antikoerper, GLI2 antikoerper, Gli2 antikoerper

Hintergrund: GLI2 encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Alias Symbols: HPE9, THP1, THP2

Protein Interaction Partner: SPOP, SKI, HDAC1, STK36, FBXW11, SUFU, ZIC2, ZIC1, CREB1, TBP,

Protein Size: 1258

Gen-ID: 2736

NCBI Accession: NM_030379, NP_084655

UniProt: P10070

Pathways: Hedgehog Signalweg, Dopaminergic Neurogenesis