KIR2DL4/CD158d Antikörper

Produktnummer ABIN509568

Produktdetails anti-KIR2DL4/CD158d Antikörper

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIR2DL4/CD158d Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: NK3.3 cells and KIR2DL4-Ig fusion protein

Klon: MAb 33

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 2-6 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-KIR2DL4/CD158d Antikörper (ABIN509568)

Rajagopalan, Bryceson, Kuppusamy, Geraghty, van der Meer, Joosten, Long: "Activation of NK cells by an endocytosed receptor for soluble HLA-G." in: PLoS biology, Vol. 4, Issue 1, pp. e9, (2006) (PubMed).

LeMaoult, Zafaranloo, Le Danff, Carosella: "HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 662-4, (2005) (PubMed).

Yan, Fan: "Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition." in: Cell research, Vol. 15, Issue 3, pp. 176-82, (2005) (PubMed).

Goodridge, Witt, Christiansen, Warren: "KIR2DL4 (CD158d) genotype influences expression and function in NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 4, pp. 1768-74, (2003) (PubMed).

Rajagopalan, Fu, Long: "Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 4, pp. 1877-81, (2001) (PubMed).

Details zu KIR2DL4/CD158d

Target: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Andere Bezeichnung: CD158d / KIR2DL4 (KIR2DL4 Produkte)

Synonyme: G9P antikoerper, CD158D antikoerper, KIR103 antikoerper, KIR103AS antikoerper, KIR2DL4 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 antikoerper, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antikoerper, KIR2DL4 antikoerper

Hintergrund: Killer cell immunoglobulin like receptor, two Ig d,CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ, secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.,KIR2DL4, KIR103AS, 103AS, 15.212

Gen-ID: 3805

UniProt: Q99706