SIGLEC10 Antikörper (Middle Region)

Produktnummer ABIN503134

Produktdetails anti-SIGLEC10 Antikörper

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Bindungsspezifität: Middle Region

Reaktivität: Human, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CHVDFSRKGV SAQRTVRLRV AYAPRDLVIS ISRDNTPALE PQPQGNVPYL

Homologie: Dog: 79%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SIGLEC10. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC10

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 697 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SIGLEC10 Antikörper (ABIN503134)

Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).

Details zu SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Andere Bezeichnung: SIGLEC10 (SIGLEC10 Produkte)

Synonyme: PRO940 antikoerper, SIGLEC-10 antikoerper, SLG2 antikoerper, Siglecg antikoerper, SIGLEC10 antikoerper, slg2 antikoerper, pro940 antikoerper, siglec-10 antikoerper, sialic acid binding Ig like lectin 10 antikoerper, sialic acid binding Ig-like lectin 10 antikoerper, sialic acid-binding Ig-like lectin 10 antikoerper, SIGLEC10 antikoerper, Siglec10 antikoerper, LOC484343 antikoerper, LOC100066644 antikoerper, siglec10 antikoerper, LOC100513863 antikoerper, LOC100340374 antikoerper

Hintergrund: SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
Protein Interaction Partner: FLNA, PTPN6,
Protein Size: 697

Molekulargewicht: 76 kDa

Gen-ID: 89790

NCBI Accession: NM_033130, NP_149121

UniProt: Q96LC7