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Vangl1 Antikörper (AA 148-400)

Vangl1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5027627
  • Target Alle Vangl1 Antikörper anzeigen
    Vangl1 (Vang-Like 1 (Vangl1))
    Bindungsspezifität
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 148-400
    Reaktivität
    • 27
    • 14
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    Human
    Wirt
    • 25
    • 3
    Kaninchen
    Klonalität
    • 27
    • 1
    Polyklonal
    Konjugat
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Vangl1 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 8
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    Protein A Chromatography
    Immunogen
    A partial length recombinant Vang like-1 protein (amino acids 148-400) was used as the immunogen for this antibody.
    Isotyp
    IgG
    Top Product
    Discover our top product Vangl1 Primärantikörper
  • Applikationshinweise
    WB: 2-4 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Target
    Vangl1 (Vang-Like 1 (Vangl1))
    Andere Bezeichnung
    Vang like-1 (Vangl1 Produkte)
    Synonyme
    stb2 antikoerper, Kitenin antikoerper, Lpp2 antikoerper, Stb2 antikoerper, Stbm antikoerper, KITENIN antikoerper, LPP2 antikoerper, STB2 antikoerper, STBM2 antikoerper, VANGL planar cell polarity protein 1 antikoerper, vang-like 1 (van gogh, Drosophila) antikoerper, Vangl1 antikoerper, vangl1 antikoerper, VANGL1 antikoerper
    Hintergrund
    Vangl1 (VANGL planar cell polarity protein 1) is an integral membrane protein that belongs to the tetraspanin family having four transmembrane domains. Tetraspanins form large multimolecular complexes on the cell membrane and are involved in cellular signaling, membrane formation, and migration. Vangl1 is expressed at the plasma membrane of different tissues and play a critical role in establishing planar cell polarity (PCP) in epithelial cells and are required for convergent extension (CE) movements during embryogenesis. It is a highly conserved and have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the vangl1 gene cause NTDs (neural tube defects). Ser/Thr phosphorylation of Vangl1 serves as an effector mediating the ITF healing response of the intestinal mucosa. In colon carcinoma cell lines, Vangl1 interacts with KAI1 (CD82) tumor metastasis suppressor. Vangl1 overexpression increases motility and metastasis, whereas its inhibition decreases motility and metastasis of colon cancer confirming migratory phenotype for Vangl1 in colonic epithelial cells.
    Molekulargewicht
    62 kDa
    Gen-ID
    81839
    UniProt
    Q8TAA9
    Pathways
    WNT Signalweg
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