SPIB Antikörper (AA 50-260)

Produktnummer ABIN5027543

Produktdetails anti-SPIB Antikörper

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Bindungsspezifität: AA 50-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPIB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Spi-B protein (amino acids 50-260) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu SPIB

Target: SPIB (Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB))

Andere Bezeichnung: Spi-B (SPIB Produkte)

Synonyme: spi-b antikoerper, spib antikoerper, spiba antikoerper, SPI-B antikoerper, B42b-like antikoerper, Spi-B antikoerper, Spi-B transcription factor L homeolog antikoerper, Spi-B transcription factor antikoerper, Spi-B transcription factor (Spi-1/PU.1 related) antikoerper, spib.L antikoerper, SPIB antikoerper, Spib antikoerper

Hintergrund: Spi-B belongs to the ETS family transcription containing a conserved ETS domain which specifically binds to a purine-rich DNA sequence called the PU-box (5'-GAGGAA-3'). Spi-B has two known isoforms (28 and 18 kDa) localized in nucleus and cytoplasm. Spi-B contains two transactivation domains (TAD) at the N- terminal end which may be required for transcriptional activation of the target genes. Spi-B is involved in development of plasmacytoid dendritic cells (natural interferon producing cells) and B-cell development. Spi-B acts as a lymphoid specific enhancer. Spi-B is highly expressed in plasmacytoid dendritic cells (pDCs), B-cells and stem cell populations of the liver.

Molekulargewicht: 28 kDa

Gen-ID: 6689

UniProt: Q01892