DDEF2 antikoerper, ddef2 antikoerper, asap2 antikoerper, si:dkey-37o8.2 antikoerper, AMAP2 antikoerper, CENTB3 antikoerper, PAG3 antikoerper, PAP antikoerper, Pap-alpha antikoerper, SHAG1 antikoerper, 6530401G17Rik antikoerper, Ddef2 antikoerper, Gm1523 antikoerper, Gm592 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b antikoerper, ASAP2 antikoerper, asap2.L antikoerper, asap1b antikoerper, asap2 antikoerper, Asap2 antikoerper
Hintergrund
ASAP2 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2) or Development and differentiation-enhancing factor 2 (DDEF2) or Paxillin-associated protein with ARF GAP activity 3 (PAG3) is a multidomain protein containing two ANK repeats, one Arf-GAP domain, one PH domain and one SH3 domain. ASAP2 has two isoforms: PAPalpha and PAPbeta (111 and 106 kDa respectively) and both the isoforms are generally located in Golgi plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). ASAP2 regulates ARF-mediated vesicle budding when vesicular transport. ASAP2 has high level of expression in brain, kidney, and heart.