CXCR2 Antikörper (N-Term)

Produktnummer ABIN502194

Produktdetails anti-CXCR2 Antikörper

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against IL8RB. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IL8RB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 360 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Andere Bezeichnung: IL8RB (CXCR2 Produkte)

Synonyme: CD182 antikoerper, CDw128b antikoerper, CMKAR2 antikoerper, IL8R2 antikoerper, IL8RA antikoerper, IL8RB antikoerper, CXC-R2 antikoerper, CXCR-2 antikoerper, CD128 antikoerper, CDw128 antikoerper, Cmkar2 antikoerper, Gpcr16 antikoerper, IL-8Rh antikoerper, IL-8rb antikoerper, Il8rb antikoerper, mIL-8RH antikoerper, C-X-C motif chemokine receptor 2 antikoerper, chemokine (C-X-C motif) receptor 2 antikoerper, Cxcr2 antikoerper, CXCR2 antikoerper

Hintergrund: IL8RB is the receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. IL8RB binds to IL-8 with high affinity. IL8RB also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CD182, CDw128b, CMKAR2, CXCR2, IL8R2, IL8RA, IL8RB
Protein Interaction Partner: ST13, RAB11FIP2, CXCL5, PPP2CA, MYO5B, PPBP, GNA14, RGS12, GPRASP1, CXCL1, CXCL8, CXCR1, CXCR2, GNAI3, GNAI2, GNA15, CXCL3, CXCL2, CXCL6, GRIA1, ARRB1, ADRA1A, GTF3A,
Protein Size: 360

Molekulargewicht: 41 kDa

Gen-ID: 3579

NCBI Accession: NM_001557, NP_001548

UniProt: P25025

Pathways: cAMP Metabolic Process