ZFP36 Antikörper (Middle Region)

Produktnummer ABIN501659

Produktdetails anti-ZFP36 Antikörper

Target: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFP36 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ZFP36. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ZFP36

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 326 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ZFP36

Target: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Andere Bezeichnung: ZFP36 (ZFP36 Produkte)

Synonyme: G0S24 antikoerper, GOS24 antikoerper, NUP475 antikoerper, RNF162A antikoerper, TIS11 antikoerper, TTP antikoerper, zfp-36 antikoerper, c3h-1 antikoerper, g0s24 antikoerper, gos24 antikoerper, nup475 antikoerper, rnf162a antikoerper, tis11 antikoerper, ttp antikoerper, ZFP36 antikoerper, C3H-1 antikoerper, Gos24 antikoerper, Nup475 antikoerper, TIS11D antikoerper, TISII antikoerper, Tis11 antikoerper, Ttp antikoerper, Zfp-36 antikoerper, ZFP36 ring finger protein antikoerper, ZFP36 ring finger protein L homeolog antikoerper, tristetraproline antikoerper, Tristetraproline antikoerper, similar to Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth antikoerper, zinc finger protein 36 antikoerper, ZFP36 antikoerper, zfp36.L antikoerper, EDI_287240 antikoerper, Bm1_42085 antikoerper, LOAG_03119 antikoerper, zfp36 antikoerper, Zfp36 antikoerper

Hintergrund: ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Alias Symbols: G0S24, GOS24, NUP475, RNF162A, TIS11, TTP
Protein Interaction Partner: YWHAB, PPP2CA, DNAJB1, DCP1B, DHX36, PRR5L, XRN1, UBC, TRAF2, EXOSC6, UPF2, EXOSC8, YWHAQ, TNF, DCP2, EDC3, DCP1A, EDC4, CDK6, APP, LIN28A, SH3KBP1, PABPC1, NCL, MAP3K4, HSPA4, HDAC7, HDAC3, NFKB1, HOXC9, HDAC1, CCDC85B, MAPKAPK2, YWHAG, SFN, HMGB1, NUP21
Protein Size: 326

Molekulargewicht: 34 kDa

Gen-ID: 7538

NCBI Accession: NM_003407, NP_003398

UniProt: P26651