TOP2B Antikörper (Middle Region)

Produktnummer ABIN501630

Produktdetails anti-TOP2B Antikörper

Target: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Meerschweinchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOP2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ENEGDYNPGR KTSKTTSKKP KKTSFDQDSD VDIFPSDFPT EPPSLPRTGR

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TOP2B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TOP2B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1621 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TOP2B

Target: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Andere Bezeichnung: TOP2B (TOP2B Produkte)

Synonyme: TOP2B antikoerper, D230016L12Rik antikoerper, Top-2 antikoerper, TOPIIB antikoerper, top2beta antikoerper, DNA topoisomerase II beta antikoerper, topoisomerase (DNA) II beta antikoerper, microRNA 4442 antikoerper, TOP2B antikoerper, Top2b antikoerper, MIR4442 antikoerper

Hintergrund: TOP2B is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants, however, the second variant has not yet been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TOPIIB, top2beta
Protein Interaction Partner: BAZ1B, SUMO2, SUMO3, UBC, EIF6, RPA3, RPA2, RPA1, ERG, WHSC1, NOTCH1, ESR1, NCSTN, SNRNP200, RBM14, HNRNPR, HDAC3, XPC, TOP2A, SNRPE, SMARCE1, SMARCD2, SMARCC2, SMARCC1, SMARCB1, SMARCA4, SMARCA2, SFPQ, S100A9, MSH2, IK, SEPT7, SUMO1, CUL5, NEDD8, RANBP2,
Protein Size: 1621

Molekulargewicht: 183 kDa

Gen-ID: 7155

NCBI Accession: NM_001068, NP_001059

UniProt: Q02880