KCNA1 Antikörper (Middle Region)

Produktnummer ABIN501356

Produktdetails anti-KCNA1 Antikörper

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ISIVIFCLET LPELKDDKDF TGTVHRIDNT TVIYNSNIFT DPFFIVETLC

Homologie: Dog: 100%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against KCNA1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 495 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KCNA1 Antikörper (ABIN501356)

Glasscock, Voigt, McCauley, Sun, Li, Chiang, Zhou, Molina, Thomas, Schmidt, Skapura, Noebels, Dobrev, Wehrens: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." in: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).

Tan, Lennon, Klein, Boeve, Pittock: "Clinical spectrum of voltage-gated potassium channel autoimmunity." in: Neurology, Vol. 70, Issue 20, pp. 1883-90, (2008) (PubMed).

Details zu KCNA1

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Andere Bezeichnung: KCNA1 (KCNA1 Produkte)

Synonyme: AEMK antikoerper, EA1 antikoerper, HBK1 antikoerper, HUK1 antikoerper, KV1.1 antikoerper, MBK1 antikoerper, MK1 antikoerper, RBK1 antikoerper, KCNA1 antikoerper, AI840627 antikoerper, Kca1-1 antikoerper, Kv1.1 antikoerper, Mk-1 antikoerper, Shak antikoerper, mceph antikoerper, Kcna antikoerper, Kcpvd antikoerper, potassium voltage-gated channel subfamily A member 1 antikoerper, potassium voltage-gated channel, shaker-related subfamily, member 1 antikoerper, fragile site, aphidicolin type, common, fra(12)(q24) antikoerper, KCNA1 antikoerper, Kcna1 antikoerper, FRA12E antikoerper

Hintergrund: KCNA1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). Sequence Note: This RefSeq record was created largely from genomic sequence because transcripts were not available for the entire length of the gene. This transcript is supported by sequences from mouse. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
Protein Interaction Partner: KCNRG, KCNE4, DLG4, DLG1, KCNA4, KCNA3, KCNA2, RTN4, CNTNAP1,
Protein Size: 495

Molekulargewicht: 56 kDa

Gen-ID: 3736

NCBI Accession: NM_000217, NP_000208

UniProt: Q09470