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XBP1 Antikörper (N-Term)

XBP1 Reaktivität: Human, Maus WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN501132
  • Target Alle XBP1 Antikörper anzeigen
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Bindungsspezifität
    • 17
    • 16
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 69
    • 42
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    Human, Maus
    Wirt
    • 68
    • 11
    • 1
    Kaninchen
    Klonalität
    • 68
    • 12
    Polyklonal
    Konjugat
    • 43
    • 7
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser XBP1 Antikörper ist unkonjugiert
    Applikation
    • 74
    • 44
    • 28
    • 19
    • 14
    • 13
    • 12
    • 9
    • 6
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse
    Aufreinigung
    Affinity chromatography
    Immunogen
    XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot. Immunohistochemistry on paraffin sections: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Andere Bezeichnung
    XBP1 / TREB5 (XBP1 Produkte)
    Synonyme
    treb5 antikoerper, xXBP1 antikoerper, xbp2 antikoerper, XBP1P1 antikoerper, XBPP1 antikoerper, xbp1 antikoerper, TREB5 antikoerper, XBP-1 antikoerper, XBP2 antikoerper, D11Ertd39e antikoerper, TREB-5 antikoerper, HTF antikoerper, cb918 antikoerper, id:ibd1195 antikoerper, trebf antikoerper, wu:fb02h05 antikoerper, wu:fb63f10 antikoerper, xbp1a antikoerper, xbp1b antikoerper, X-box binding protein 1 antikoerper, X-box binding protein 1 L homeolog antikoerper, xbp1 antikoerper, XBP1 antikoerper, Xbp1 antikoerper, xbp1.L antikoerper
    Hintergrund
    X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
    Gen-ID
    7494
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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