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MAVS Antikörper (Middle Region)

MAVS Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN501120
  • Target Alle MAVS Antikörper anzeigen
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Bindungsspezifität
    • 15
    • 13
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 49
    • 38
    • 4
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 70
    • 7
    Kaninchen
    Klonalität
    • 72
    • 5
    Polyklonal
    Konjugat
    • 35
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAVS Antikörper ist unkonjugiert
    Applikation
    • 69
    • 37
    • 13
    • 13
    • 11
    • 9
    • 9
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MAVS at Center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Affinity chromatography
    Immunogen
    VISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Andere Bezeichnung
    MAVS (MAVS Produkte)
    Synonyme
    CARDIF antikoerper, IPS-1 antikoerper, IPS1 antikoerper, VISA antikoerper, D430028G21Rik antikoerper, Visa antikoerper, cardif antikoerper, wu:fj20d04 antikoerper, zgc:158392 antikoerper, mitochondrial antiviral signaling protein antikoerper, MAVS antikoerper, Mavs antikoerper, mavs antikoerper
    Hintergrund
    Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.Synonyms: CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1
    Gen-ID
    57506
    NCBI Accession
    NP_065797
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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