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TSC1 Antikörper (both Isoforms, Middle Region)

TSC1 Reaktivität: Human, Maus, Ratte WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN501071
  • Target Alle TSC1 Antikörper anzeigen
    TSC1 (Tuberous Sclerosis 1 (TSC1))
    Bindungsspezifität
    • 24
    • 16
    • 16
    • 16
    • 15
    • 15
    • 13
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    both Isoforms, Middle Region
    Reaktivität
    • 187
    • 138
    • 52
    • 24
    • 18
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 301
    • 16
    • 1
    • 1
    Kaninchen
    Klonalität
    • 303
    • 16
    Polyklonal
    Konjugat
    • 113
    • 37
    • 36
    • 36
    • 32
    • 32
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser TSC1 Antikörper ist unkonjugiert
    Applikation
    • 230
    • 208
    • 91
    • 28
    • 26
    • 26
    • 15
    • 14
    • 9
    • 7
    • 6
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects TSC1 / Hamartin at Center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    TSC1 antibody was raised against a 15 amino acid peptide from the middle region of human TSC1. TSC1 antibody will recognize both isoforms of TSC1.
    Isotyp
    IgG
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    Discover our top product TSC1 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    TSC1 (Tuberous Sclerosis 1 (TSC1))
    Andere Bezeichnung
    TSC1 / Hamartin (TSC1 Produkte)
    Synonyme
    LAM antikoerper, TSC antikoerper, hamartin antikoerper, mKIAA0243 antikoerper, tsc1 antikoerper, wu:fc38b04 antikoerper, fa99f04 antikoerper, wu:fa99f04 antikoerper, zgc:63657 antikoerper, TSC complex subunit 1 antikoerper, tuberous sclerosis 1 antikoerper, TSC complex subunit 1b antikoerper, TSC complex subunit 1a antikoerper, TSC1 antikoerper, Tsc1 antikoerper, tsc1b antikoerper, tsc1 antikoerper, tsc1a antikoerper
    Hintergrund
    Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein
    Gen-ID
    7248
    Pathways
    RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation
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