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IFIH1 Antikörper (Center)

IFIH1 Reaktivität: Human, Maus WB, IF, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500266
  • Target Alle IFIH1 Antikörper anzeigen
    IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
    Bindungsspezifität
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 41
    • 13
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 33
    • 8
    • 2
    Kaninchen
    Klonalität
    • 34
    • 9
    Polyklonal
    Konjugat
    • 32
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IFIH1 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 17
    • 14
    • 8
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects Helicard at Center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse
    Aufreinigung
    Peptide Affinity Chromatography
    Immunogen
    16 amino acid peptide from near the center of Human MDA5.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
    Andere Bezeichnung
    Helicard (IFIH1 Produkte)
    Synonyme
    MDA5 antikoerper, Hlcd antikoerper, IDDM19 antikoerper, MDA-5 antikoerper, RLR-2 antikoerper, 9130009C22Rik antikoerper, Helicard antikoerper, RGD1560496 antikoerper, interferon induced with helicase C domain 1 antikoerper, IFIH1 antikoerper, Ifih1 antikoerper
    Hintergrund
    The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.Synonyms: Helicase with 2 CARD domains, IFIH1, Interferon-induced helicase C domain-containing protein 1, MDA5, Melanoma differentiation-associated protein 5, Murabutide down-regulated protein, RH116, RNA helicase-DEAD box protein 116
    Gen-ID
    64135
    NCBI Accession
    NP_071451
    UniProt
    Q9BYX4
    Pathways
    Activation of Innate immune Response
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