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MARCH8 Antikörper (C-Term)

MARCH8 Reaktivität: Human, Maus, Ratte WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500234
  • Target Alle MARCH8 Antikörper anzeigen
    MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
    Bindungsspezifität
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 30
    • 26
    • 25
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 29
    • 1
    Kaninchen
    Klonalität
    • 30
    Polyklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MARCH8 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 13
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MARCH8.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    MARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.
    Isotyp
    IgG
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    Discover our top product MARCH8 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))
    Andere Bezeichnung
    MARCH8 (MARCH8 Produkte)
    Synonyme
    MARCH-VIII antikoerper, MIR antikoerper, RNF178 antikoerper, c-MIR antikoerper, zgc:171495 antikoerper, 1300017E09Rik antikoerper, Mir antikoerper, Mar-08 antikoerper, MARCH8 antikoerper, membrane associated ring-CH-type finger 8 antikoerper, membrane-associated ring finger (C3HC4) 8 antikoerper, membrane associated ring-CH-type finger 8 L homeolog antikoerper, MARCH8 antikoerper, march8 antikoerper, March8 antikoerper, march8.L antikoerper
    Hintergrund
    MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.Synonyms: Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCH8, MARCH-VIII, Membrane-associated RING finger protein 8, RING finger protein 178, RNF178, c-MIR
    Gen-ID
    220972
    NCBI Accession
    NP_659458
    UniProt
    Q5T0T0
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