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IL-31 Antikörper (Intermediate Domain)

IL31 Reaktivität: Human, Maus WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500006
  • Target Alle IL-31 (IL31) Antikörper anzeigen
    IL-31 (IL31) (Interleukin 31 (IL31))
    Bindungsspezifität
    • 15
    • 13
    • 10
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reaktivität
    • 57
    • 9
    • 9
    Human, Maus
    Wirt
    • 51
    • 19
    • 1
    Kaninchen
    Klonalität
    • 51
    • 20
    Polyklonal
    Konjugat
    • 33
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL-31 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 30
    • 22
    • 14
    • 14
    • 14
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    IL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human IL-31 (Intermediate Domain) Peptide
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    ELISA. Western Blot: 2.5 - 5 μg/mL. Despite its predicted size, IL-31 runs at approximately 27 - 30 kDa in SDS-PAGE.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Target
    IL-31 (IL31) (Interleukin 31 (IL31))
    Andere Bezeichnung
    Interleukin-31 / IL31 (IL31 Produkte)
    Synonyme
    IL-31 antikoerper, 1700013B14Rik antikoerper, IL31 antikoerper, interleukin 31 antikoerper, IL31 antikoerper, Il31 antikoerper
    Hintergrund
    Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).Synonyms: IL-31
    Gen-ID
    386653
    NCBI Accession
    NP_001014358
    UniProt
    Q6EBC2
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