DACT2 Antikörper (N-Term)

Produktnummer ABIN499702

Produktdetails anti-DACT2 Antikörper

Target: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DACT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to DACT2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Dact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Referenzen für anti-DACT2 Antikörper (ABIN499702)

Tan, Li, Huang, Cheng, Zhao, Chen, Chen, Tang, Zhang, Huang, Cheng: "Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway." in: Cell death & disease, Vol. 8, Issue 8, pp. e2981, (2018) (PubMed).

Zhao, Herman, Brock, Sheng, Zhang, Liu, Guo: "Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling." in: PLoS ONE, Vol. 9, Issue 11, pp. e112336, (2015) (PubMed).

Details zu DACT2

Target: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Andere Bezeichnung: DACT2 (DACT2 Produkte)

Synonyme: 2900084M21Rik antikoerper, A630024E20 antikoerper, Dpr2 antikoerper, Frd2 antikoerper, dapper2 antikoerper, C6orf116 antikoerper, DAPPER2 antikoerper, DPR2 antikoerper, RP11-503C24.7 antikoerper, bA503C24.7 antikoerper, dishevelled binding antagonist of beta catenin 2 antikoerper, dishevelled-binding antagonist of beta-catenin 2 antikoerper, DACT2 antikoerper, Dact2 antikoerper

Hintergrund: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.Synonyms: C6orf116, DAPPER2, DPR2, PP13671, dapper homolog 2

Gen-ID: 168002

NCBI Accession: NP_999627

UniProt: Q5SW24