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Caspase 12 Antikörper (Intermediate Domain)

CASP12 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499549
  • Target Alle Caspase 12 (CASP12) Antikörper anzeigen
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Bindungsspezifität
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intermediate Domain
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 88
    • 3
    • 1
    Kaninchen
    Klonalität
    • 89
    • 3
    Polyklonal
    Konjugat
    • 39
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Caspase 12 Antikörper ist unkonjugiert
    Applikation
    • 78
    • 40
    • 29
    • 28
    • 26
    • 26
    • 20
    • 19
    • 10
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    Caspase-12 antibody was raised against a peptide corresponding to amino acids 100 to 116 of murine caspase-12.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Mouse Caspase-12 (Intermediate Domain) Peptide
    Isotyp
    IgG
    Top Product
    Discover our top product CASP12 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: Caspase-12 antibody can be used for detection of caspase-12 at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Andere Bezeichnung
    Caspase-12 (CASP12 Produkte)
    Synonyme
    Caspase-12 antikoerper, CASP-12 antikoerper, CASP12P1 antikoerper, caspase 12 antikoerper, caspase 12 (gene/pseudogene) antikoerper, Casp12 antikoerper, CASP12 antikoerper
    Hintergrund
    Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including beta-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).Synonyms: CASP-12, CASP12, Inactive caspase-12
    Gen-ID
    100044205
    UniProt
    O08736
    Pathways
    Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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