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Carabin Antikörper (C-Term)

TBC1D10C Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499529
  • Target Alle Carabin (TBC1D10C) Antikörper anzeigen
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 8
    • 1
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 9
    Dieser Carabin Antikörper ist unkonjugiert
    Applikation
    • 9
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to Carabin.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
    Isotyp
    IgG
    Top Product
    Discover our top product TBC1D10C Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
    Andere Bezeichnung
    Carabin (TBC1D10C Produkte)
    Synonyme
    CARABIN antikoerper, EPI64C antikoerper, 1810062O14Rik antikoerper, AI428527 antikoerper, RGD1311490 antikoerper, TBC1 domain family member 10C antikoerper, TBC1 domain family, member 10c antikoerper, TBC1 domain family, member 10C antikoerper, TBC1D10C antikoerper, Tbc1d10c antikoerper
    Hintergrund
    Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
    Gen-ID
    374403
    NCBI Accession
    NP_940919
    UniProt
    Q8IV04
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