BRSK1 Antikörper (Center)

Produktnummer ABIN499501

Produktdetails anti-BRSK1 Antikörper

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRSK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to BRSK1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: BRSK1 antibody was raised against a 28 amino acid peptide from near the center of human BRSK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BRSK1 antibody can be used for detection of BRSK1 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BRSK1

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Andere Bezeichnung: BRSK1 (BRSK1 Produkte)

Synonyme: BRSK1 antikoerper, hSAD1 antikoerper, Gm1100 antikoerper, SAD-B antikoerper, SADB antikoerper, RGD1563268 antikoerper, Sad-b antikoerper, BR serine/threonine kinase 1 antikoerper, BRSK1 antikoerper, Brsk1 antikoerper

Hintergrund: BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.Synonyms: BR serine/threonine-protein kinase 1, KIAA1811, SAD-B, SAD1, SAD1 kinase, Serine/threonine kinase SAD-B

Gen-ID: 84446

UniProt: Q8TDC3