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APP Antikörper (N-Term)

APP Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499321
  • Target Alle APP Antikörper anzeigen
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Bindungsspezifität
    • 30
    • 28
    • 24
    • 24
    • 21
    • 18
    • 12
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 275
    • 121
    • 114
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 237
    • 72
    • 5
    • 5
    • 1
    Kaninchen
    Klonalität
    • 257
    • 63
    Polyklonal
    Konjugat
    • 149
    • 31
    • 23
    • 23
    • 12
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser APP Antikörper ist unkonjugiert
    Applikation
    • 213
    • 158
    • 93
    • 52
    • 52
    • 51
    • 41
    • 41
    • 30
    • 26
    • 16
    • 11
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to APP.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    APP antibody was raised against an 18 amino acid peptide near the amino terminus of human APP.
    Isotyp
    IgG
    Top Product
    Discover our top product APP Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: APP antibody can be used for detection of APP at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, (2009) (PubMed).

  • Target
    APP (Amyloid beta (A4) Precursor Protein (APP))
    Andere Bezeichnung
    Amyloid beta A4 Protein / APP (APP Produkte)
    Synonyme
    AAA antikoerper, ABETA antikoerper, ABPP antikoerper, AD1 antikoerper, APPI antikoerper, CTFgamma antikoerper, CVAP antikoerper, PN-II antikoerper, PN2 antikoerper, aaa antikoerper, abeta antikoerper, abpp antikoerper, ad1 antikoerper, appi antikoerper, ctfgamma antikoerper, cvap antikoerper, pn2 antikoerper, APP antikoerper, APP-like antikoerper, APPL antikoerper, Abeta antikoerper, BcDNA:GH04413 antikoerper, CG7727 antikoerper, Dmel\\CG7727 antikoerper, EG:65F1.5 antikoerper, appl antikoerper, Abpp antikoerper, Adap antikoerper, Ag antikoerper, Cvap antikoerper, E030013M08Rik antikoerper, betaApp antikoerper, app antikoerper, wu:fj34d10 antikoerper, wu:fk65e12 antikoerper, zgc:85740 antikoerper, amyloid beta precursor protein antikoerper, amyloid beta (A4) precursor protein antikoerper, beta amyloid protein precursor-like antikoerper, amyloid beta (A4) precursor protein a antikoerper, amyloid beta precursor protein L homeolog antikoerper, APP antikoerper, app antikoerper, Appl antikoerper, App antikoerper, appa antikoerper, app.L antikoerper
    Hintergrund
    Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimers disease patients' brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the Beta-amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimers disease.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
    Gen-ID
    1238255
    UniProt
    P05067
    Pathways
    Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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