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MYO5A Antikörper (Internal Region)

MYO5A Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, IF, EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN499147
  • Target Alle MYO5A Antikörper anzeigen
    MYO5A (Myosin VA (MYO5A))
    Bindungsspezifität
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    Human, Maus, Ratte, Rind (Kuh)
    Wirt
    • 21
    • 1
    Ziege
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MYO5A Antikörper ist unkonjugiert
    Applikation
    • 11
    • 10
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Sequenz
    C-ETKQLELDLN
    Spezifität
    This antibody is expected to recognize both reported isoforms (NP_000250.3 and NP_001135967.1).
    Kreuzreaktivität (Details)
    Species reactivity (expected):Rat, Bovine.
    Species reactivity (tested):Human, Mouse.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide sequence from the internal region of the protein sequence according to NP_000250.3, NP_001135967.1. Genename: MYO5A
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  • Applikationshinweise
    Peptide ELISA: Limit Dilution: 1/8000. Western blot: 1-3 μg/mL. This antibody detects a band of approx. 200 kDa in lysates of cell lineJurkat.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    MYO5A (Myosin VA (MYO5A))
    Andere Bezeichnung
    Myosin-Va (MYO5A Produkte)
    Synonyme
    myo5a antikoerper, MGC53270 antikoerper, si:dkey-266j9.1 antikoerper, MYOA antikoerper, MYO5A antikoerper, D antikoerper, Dop antikoerper, Myh12 antikoerper, 9630007J19Rik antikoerper, AI413174 antikoerper, AI661011 antikoerper, Dbv antikoerper, MVa antikoerper, Myo5 antikoerper, MyoVA antikoerper, Sev-1 antikoerper, d antikoerper, d-120J antikoerper, flail antikoerper, flr antikoerper, DILUTE antikoerper, myoxin) antikoerper, non-muscle antikoerper, GS1 antikoerper, MYH12 antikoerper, MYO5 antikoerper, MYR12 antikoerper, myosin VA L homeolog antikoerper, myosin VAa antikoerper, myosin VA antikoerper, myosin va antikoerper, myo5a.L antikoerper, myo5aa antikoerper, MYO5A antikoerper, PY04789 antikoerper, Myo5a antikoerper
    Hintergrund
    Myosin-Va has been implicated in the regulation of vesicle trafficking in neurons and melanocytes. It has been suggested that class V myosins associate with membrane vesicles through their C-terminal tails. Myosin V associates with synaptic vesicles and forms a stable complex with the synaptic vesicle membrane proteins, synaptobrevin II, and synaptophysin. The dilute Myo5a gene mutation in myosin Va leads to mental retardation, variable cellular immunodeficiency and impaired melanocyte function (pigmentary dilution), known as Griscelli syndrome in humans. Myosin Va regulates melanosome distribution along microfilaments. It is found in association with the centrosome at all stages of the cell cycle. In the interphase stage, myosin Va is found in pericentriolar material. During cell division, it is found in the cytoplasm and concentrates in a trail between migrating centrioles and in the mitotic spindle poles and spindle fibers.Synonyms: Dilute myosin heavy chain, MYH12, MYO5A, Myosin heavy chain 12, Myoxin, non-muscle
    Molekulargewicht
    215kDa (NP_000250.3).
    Gen-ID
    4644
    NCBI Accession
    NP_000250
    UniProt
    Q9Y4I1
    Pathways
    Hormone Transport, Peptide Hormone Metabolism
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