PRSS3 Antikörper

Produktnummer ABIN498692

Produktdetails anti-PRSS3 Antikörper

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRSS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of Trypsin- 3 protein. (region surrounding Met166)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PRSS3

Target: PRSS3 (Protease, serine, 3 (PRSS3))

Andere Bezeichnung: Trypsin-3 / PRSS3 (PRSS3 Produkte)

Synonyme: MTG antikoerper, PRSS4 antikoerper, T9 antikoerper, TRY3 antikoerper, TRY4 antikoerper, Try3 antikoerper, Tb antikoerper, prss3 antikoerper, protease, serine 3 antikoerper, trypsin-3 antikoerper, protease, serine, 3 antikoerper, trypsin III antikoerper, protease, serine 3 L homeolog antikoerper, PRSS3 antikoerper, CpipJ_CPIJ016105 antikoerper, Prss3 antikoerper, trp-iii antikoerper, prss3.L antikoerper

Hintergrund: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease Trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3 is expressed in the brain in addition to the pancreas.Synonyms: Brain trypsinogen, Mesotrypsinogen, PRSS4, Serine protease 3, Serine protease 4, TRY3, TRY4, Trypsin III, Trypsin IV

Molekulargewicht: approx. 32 kDa

Gen-ID: 5646

NCBI Accession: NP_002762

UniProt: P35030