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Translin Antikörper

TSN Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN498344
  • Target Alle Translin (TSN) Antikörper anzeigen
    Translin (TSN)
    Reaktivität
    • 32
    • 12
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 31
    • 1
    Kaninchen
    Klonalität
    • 32
    Polyklonal
    Konjugat
    • 17
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser Translin Antikörper ist unkonjugiert
    Applikation
    • 26
    • 19
    • 17
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This Antibody detects endogenous levels of Translin protein. (region surrounding Glu121)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Aufreinigung
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product TSN Primärantikörper
  • Applikationshinweise
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Translin (TSN)
    Abstract
    TSN Produkte
    Synonyme
    tsn antikoerper, MGC52533 antikoerper, TSN antikoerper, CG11761 antikoerper, Dmel\\CG11761 antikoerper, TB-RBP antikoerper, BCLF-1 antikoerper, C3PO antikoerper, RCHF1 antikoerper, REHF-1 antikoerper, TBRBP antikoerper, TRSLN antikoerper, 2610034C24Rik antikoerper, AU040286 antikoerper, translin L homeolog antikoerper, translin antikoerper, haloacid dehalogenase antikoerper, Translin antikoerper, tsn.L antikoerper, TSN antikoerper, trsn antikoerper, MMAH_RS03470 antikoerper, TAGG_RS05275 antikoerper, Igag_0962 antikoerper, MFER_RS03645 antikoerper, DESMU_RS01315 antikoerper, ARCVE_RS05265 antikoerper, MZHIL_RS01310 antikoerper, Tsn antikoerper
    Hintergrund
    Translin, also designated testis brain RNA-binding protein (TB-RBP), is a single-stranded DNA- and RNA-binding protein that binds to the 3' UTR regions (Y and H elements) of stored mRNAs, which suppresses their in vitro translation. The human translin gene maps to chromosome 2q21.1 and encodes a 26 kDa protein that has been highly conserved throughout evolution. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation. Association with Trax (translin-associated factor X), inhibits the binding of translin to RNA, but enhances its binding to single stranded DNA sequences. Breakpoints in the TLS/FUS and CHOP loci contain consensus recognition motifs of translin, which associates with chromosomal translocations in liposarcomas.
    Molekulargewicht
    approx. 26 kDa
    Gen-ID
    7247
    NCBI Accession
    NP_004613
    UniProt
    Q15631
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