SNAIL Antikörper

Produktnummer ABIN498268

Produktdetails anti-SNAIL Antikörper

Target: SNAIL (SNAI1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of SNAI 1 protein. (region surrounding Ala242)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-SNAIL Antikörper (ABIN498268)

Huang, Yu, Fu, Chen, Liu, Li, Xia, Zhang, Li: "EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma." in: BMC cell biology, Vol. 14, pp. 13, (2013) (PubMed).

Yao, Li, Xiong, Li, Jiang, Chen: "A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells." in: Cell and tissue research, Vol. 353, Issue 3, pp. 409-23, (2013) (PubMed).

Pan, Xiong, Yao, Xin, Zhang, Chen: "Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 998-1008, (2012) (PubMed).

Zou, Luo, Zeng, Dong, Wu, Liu: "Protein kinase CK2? is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes." in: Journal of translational medicine, Vol. 9, pp. 97, (2011) (PubMed).

Yang, Feng, Zhou, Liang, Mao, Deng, Yan, Sun, Du, Liu, Wang, Neckenig, Yang, Qu: "Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression." in: Cancer science, Vol. 102, Issue 7, pp. 1264-71, (2011) (PubMed).

Feng, Di, Tao, Chang, Lu, Fan, Shan, Li, Yang: "PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development." in: Molecular and cellular biology, Vol. 30, Issue 14, pp. 3711-21, (2010) (PubMed).

Details zu SNAIL

Target: SNAIL (SNAI1)

Andere Bezeichnung: SNAI1 (SNAI1 Produkte)

Synonyme: SLUGH2 antikoerper, SNA antikoerper, SNAH antikoerper, SNAIL antikoerper, SNAIL1 antikoerper, dJ710H13.1 antikoerper, AI194338 antikoerper, Sna antikoerper, Sna1 antikoerper, Snail antikoerper, Snail1 antikoerper, SNAI1 antikoerper, BG:DS01845.1 antikoerper, CG3956 antikoerper, Dmel\\CG3956 antikoerper, Sco antikoerper, br28 antikoerper, br29 antikoerper, l(2)35Db antikoerper, l(2)br28 antikoerper, l(2)br29 antikoerper, l(3)br28 antikoerper, l35Db antikoerper, sn antikoerper, Xsnail antikoerper, sna antikoerper, snail1 antikoerper, xSna antikoerper, Snai antikoerper, sna2 antikoerper, snail2 antikoerper, cb643 antikoerper, sna-1 antikoerper, sna1 antikoerper, snai1 antikoerper, snail1a antikoerper, zgc:109820 antikoerper, snail family transcriptional repressor 1 antikoerper, snail family zinc finger 1 antikoerper, snail homolog 1 (Drosophila) antikoerper, snail antikoerper, zinc-finger transcription factor Snail antikoerper, snail family zinc finger 1 S homeolog antikoerper, protein escargot antikoerper, transcription factor protein antikoerper, snail zinc finger protein antikoerper, snail family zinc finger 1b antikoerper, snail family zinc finger 1a antikoerper, SNAI1 antikoerper, Snai1 antikoerper, sna antikoerper, snail antikoerper, snai1.S antikoerper, LOC410464 antikoerper, snai1b antikoerper, snai1a antikoerper

Hintergrund: The SNAIL family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sn,a each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3. The SNAIL-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger domains at the C-terminal region of Smuc.Synonyms: Protein snail homolog 1, SNAH, Zinc finger protein SNAI1

Molekulargewicht: approx. 29 kDa

Gen-ID: 6615

NCBI Accession: NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling