KIR2DL4/CD158d Antikörper (PE)
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- Target Alle KIR2DL4/CD158d (KIR2DL4) Antikörper anzeigen
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser KIR2DL4/CD158d Antikörper ist konjugiert mit PE
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- NK3.3 cells and KIR2DL4-Ig fusion protein
- Klon
- MAb 33
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product KIR2DL4 Primärantikörper
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- Applikationshinweise
- Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
- Kommentare
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- No reconstitution is necessary.
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
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Do not freeze.
Avoid prolonged exposure to light. - Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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Activation of NK cells by an endocytosed receptor for soluble HLA-G." in: PLoS biology, Vol. 4, Issue 1, pp. e9, (2006) (PubMed).
: "HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 662-4, (2005) (PubMed).
: "Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition." in: Cell research, Vol. 15, Issue 3, pp. 176-82, (2005) (PubMed).
: "KIR2DL4 (CD158d) genotype influences expression and function in NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 4, pp. 1768-74, (2003) (PubMed).
: "Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 4, pp. 1877-81, (2001) (PubMed).
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Activation of NK cells by an endocytosed receptor for soluble HLA-G." in: PLoS biology, Vol. 4, Issue 1, pp. e9, (2006) (PubMed).
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- Target
- KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
- Andere Bezeichnung
- CD158d / KIR2DL4 (KIR2DL4 Produkte)
- Synonyme
- G9P antikoerper, CD158D antikoerper, KIR103 antikoerper, KIR103AS antikoerper, KIR2DL4 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 antikoerper, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antikoerper, KIR2DL4 antikoerper
- Hintergrund
- Killer cell immunoglobulin like receptor, two Ig d,CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ, secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.,KIR2DL4, KIR103AS, 103AS, 15.212
- Gen-ID
- 3805
- UniProt
- Q99706
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