IL-1 R1 Antikörper

Antigen: IL-1 R1

Klonalität: Monoklonal (JAMA-147)

Wirt: Armenischer Hamster

Reaktivität: Maus

Applikation: Durchflusszytometrie (FACS), Immunpräzipitation (IP)

Produktnummer: ABIN488769

Produktbeschreibung

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: JAMA-147

Beschreibung: IL-1 was one of the first cytokines to be described. The IL-1 family consists of three members including IL-1a, IL-1 and IL-1 receptor antagonist (IL-1Ra). IL-1a and IL-1 produce similar or identical biological responses and IL-1Ra is an endogenous inhibitor that blocks and buffers IL-1a and IL-1 actions. Each family member is expressed by a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1a is retained inside of the cell or is expressed on the cell surface and acts as an autocrine messenger, while IL-1 is secreted. IL-1a and IL-1 elicit a broad range of actions including induction of fever, hypotension, stimulation of thymocyte proliferation, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Binding of IL-1a by ALF-161 neutralizes the biological effects of IL-1a.

Spezifität: Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Anwendungen

Applikationshinweise: FC, IP. Each Investigator should determine their own optimal working dilution for specific applications.

Konzentration: 0.1 mg/ml

Reinigung: Purified

Buffer: This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Storage and Stability This antibody is stable when stored at 2-8C. Do not freeze. Reported Applications FC

Lagerung: This antibody is stable when stored at 2-8°C. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar