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Acetylated Lysine Antikörper

WB, ELISA, IP, IHC, IF, ICC Wirt: Maus Monoclonal 7F8 unconjugated
Produktnummer ABIN488678
  • Target Alle Acetylated Lysine Produkte
    Acetylated Lysine
    Reaktivität
    Bitte anfragen
    Wirt
    • 29
    • 24
    Maus
    Klonalität
    • 27
    • 25
    Monoklonal
    Konjugat
    • 23
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Acetylated Lysine Antikörper ist unkonjugiert
    Applikation
    • 50
    • 39
    • 35
    • 23
    • 12
    • 12
    • 11
    • 11
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    The antibody detects proteins containing acetylated lysine residues in ELISA and WBs. Does not detect non-acetylated lysine residues.
    Kreuzreaktivität (Details)
    Not reactive in: no confirmed exceptions from predicted reactivity known in the moment
    Homologie
    higher plants
    Aufreinigung
    affinity purified
    Immunogen
    acetylated KLH
    Klon
    7F8
    Isotyp
    IgG1
  • Applikationshinweise
    1: 100 (IHC), 1: 1000 (WB), for other assays optimal dilution has to be determined by end user
    Kommentare

    1 µg of this antibody is sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20 µg total protein and ECL detection system

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    protein G purified IgG2B in PBS, pH 7.4 with 0.09 % sodium azide and 50 %glycerol at concentration 1 mg/mL
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    store at -20°C, avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
  • Target
    Acetylated Lysine
    Abstract
    Acetylated Lysine Produkte
    Synonyme
    C-K-RAS antikoerper, CFC2 antikoerper, K-RAS2A antikoerper, K-RAS2B antikoerper, K-RAS4A antikoerper, K-RAS4B antikoerper, KI-RAS antikoerper, KRAS1 antikoerper, KRAS2 antikoerper, NS antikoerper, NS3 antikoerper, RASK2 antikoerper, KRAS proto-oncogene, GTPase antikoerper, KRAS antikoerper
    Substanzklasse
    Chemical
    Hintergrund
    Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3).
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