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Doublecortin Antikörper (N-Term)

DCX Reaktivität: Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4886559
  • Target Alle Doublecortin (DCX) Antikörper anzeigen
    Doublecortin (DCX)
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 74-100, N-Term
    Reaktivität
    • 111
    • 72
    • 66
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus, Ratte
    Wirt
    • 101
    • 12
    • 2
    • 2
    Kaninchen
    Klonalität
    • 96
    • 21
    Polyklonal
    Konjugat
    • 64
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Doublecortin Antikörper ist unkonjugiert
    Applikation
    • 74
    • 41
    • 33
    • 13
    • 12
    • 11
    • 9
    • 8
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.
    Sequenz
    QSLRFHQNME LDFGHFDERD KTSRNMR
    Kreuzreaktivität (Details)
    Predicted Cross Reactivity: human
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Neuronal migration protein doublecortin(DCX) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: doublecortin
    Protein Name: Neuronal migration protein doublecortin
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human Doublecortin (74-100aa QSLRFHQNMELDFGHFDERDKTSRNMR).
    Isotyp
    IgG
    Top Product
    Discover our top product DCX Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Zhang, Du, Yang, Wang, Yu, Huang, Hu, Liu, Fu: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." in: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).

  • Target
    Doublecortin (DCX)
    Andere Bezeichnung
    DCX (DCX Produkte)
    Synonyme
    DCX antikoerper, DBCN antikoerper, DC antikoerper, LISX antikoerper, SCLH antikoerper, XLIS antikoerper, Dbct antikoerper, 18C15.5 antikoerper, doublecortin antikoerper, DCX antikoerper, Dcx antikoerper
    Hintergrund
    Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

    Synonyms: DBCN | Dbct | DC | DCX | Doublecortex | Doublin | Lis X | Lis-X | Lissencephalin X | Lissencephalin-X | LISX | SCLH | XLIS | O43602
    Gen-ID
    1641
    UniProt
    O43602
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