5'-AMP-activated protein kinase catalytic subunit alpha-1 Antikörper

Antigen: 5'-AMP-activated protein kinase catalytic subunit alpha-1

Klonalität: Monoklonal (4F1-E2-E4-H9-B11)

Wirt: Maus

Reaktivität: Human

Applikation: ELISA, Western Blot (WB)

Produktnummer: ABIN488234

Produktbeschreibung

Gen-ID: PRKAA1

Swiss-Prot: Q13131

Immunogen: A synthetic peptide, CGGGAEKQKHDGRVKIGHY, corresponding to N terminal amino acids 13aa-27aa of human PRKAA1.

Format: Purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 4F1-E2-E4-H9-B11

Beschreibung: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Caution hazardous ingredient: Sodium azide, avoid exposure to skin and eyes, ingestion, and contact with heat, acids, and metals or metal ions. Wash exposed skin with soap and water. Flush eyes with water. Do not discard into plumbing.

Spezifität: Mouse monoclonal to PRKAA1

Anwendungen

Applikationshinweise: ELISA: 1/5000 – 1/20000. WB: 1/100-1/2000

Konzentration: 1. 000mg/ml

Reinheit: > 90%

Reinigung: Protein G-Sepharose affinity purified

Buffer: Preservative: 0. 02% Sodium Azide and 50% glycerol, 1% BSA, PBS, PH7. 4.

Lagerung: Store at -20°C. Avoid repeated freeze / thaw cycles. Ship at 4°-10°

Forschungsgebiet: Krebs, Signaltransduktion, Metabolismus, Kardiovaskuläres System, Hormone, Fettsäuren, Neurogenese, Alzheimer-Krankheit (Morbus Alzheimer)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

PRKAA1 antibody at 1/1000 dilution + MCF7 whole cell lysate 40ug/lane, Predicted band size: 62kDa, Observed band size: 62kDa