SLC1A2 Antikörper (N-Term)

Produktnummer ABIN487119

Produktdetails anti-SLC1A2 Antikörper

Target: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC1A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PGNPKLKKQL GPGKKNDEVS SLDAFLDLIR NLFPENLVQA CFQQIQTVTK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against SLC1A2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC1A2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 574 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SLC1A2 Antikörper (ABIN487119)

Pretto, Kumar, Cao, Cunningham, Durbin-Johnson, Qi, Berman, Noctor, Hagerman, Pessah, Tassone et al.: "Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated ..." in: Neurobiology of aging, Vol. 35, Issue 5, pp. 1189-97, (2014) (PubMed).

Details zu SLC1A2

Target: SLC1A2 (Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2))

Andere Bezeichnung: SLC1A2 (SLC1A2 Produkte)

Synonyme: CG3159 antikoerper, Dmel\\CG3159 antikoerper, EAAT antikoerper, dEAAT2 antikoerper, dEaat2 antikoerper, Eaat antikoerper, GB16377 antikoerper, EAAT2 antikoerper, SLC1A2 antikoerper, Eaat2 antikoerper, Glt antikoerper, Glt-1 antikoerper, GLT-1 antikoerper, 1700091C19Rik antikoerper, 2900019G14Rik antikoerper, AI159670 antikoerper, GLT1 antikoerper, MGLT1 antikoerper, eaat2 antikoerper, fj34b12 antikoerper, slc1a2 antikoerper, wu:fj34b12 antikoerper, zgc:65897 antikoerper, Excitatory amino acid transporter 2 antikoerper, excitatory amino acid transporter 2 antikoerper, solute carrier family 1 member 2 antikoerper, solute carrier family 1 (glial high affinity glutamate transporter), member 2 antikoerper, solute carrier family 1 (glial high affinity glutamate transporter), member 2b antikoerper, Eaat2 antikoerper, Eaat-2 antikoerper, SLC1A2 antikoerper, VDBG_06180 antikoerper, EUBELI_01747 antikoerper, Trebr_0139 antikoerper, Slc1a2 antikoerper, slc1a2b antikoerper

Hintergrund: SLC1A2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EAAT2, GLT-1
Protein Interaction Partner: PML, GRB2, AJUBA, SLC1A2, MYCN, RELA,
Protein Size: 574

Molekulargewicht: 62 kDa

Gen-ID: 6506

NCBI Accession: NM_004171, NP_004162

UniProt: P43004

Pathways: Dicarboxylic Acid Transport