Gap Junction Protein, alpha 1, 43kd (GJA1) (pSer367) Antikörper

Antigen: Gap Junction Protein, alpha 1, 43kd (GJA1)

Synonyme: CX43, GJAL, ODDD, DFNB38, Cx43, Npm1, Cnx43, Gja-1, AU042049, AW546267, Cx43alpha1, connexin43, Cx32, Cnx32, Gjb-1, MGC6217, AI118175, MGC93610, gja1, cx43a1, zfCx43.3, MGC128721, gja1-A, connexin 43, cx43, gjal, oddd, dfnb38, CONNEXIN 43

Epitope: pSer367

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN461476

Produktbeschreibung

Weitere Bezeichnung: Connexin 43

Format: Liquid

Beschreibung: The connexins are a group of GAP junction proteins, which form a hexamer to compose a connexon. Clusters of connexons form a GAP junction through which low molecular weight proteins may diffuse from cell to cell. Several mammalian cells with malignant phenotypes exhibit decreased connexin expression and GAP junction communication. There is a decrease in GAP junctional communication in Src transformed cells. The decreased communication appears to be associated with tyrosine phosphorylation of connexin 43. Activated c-Src phosphorylates the C-terminal tail of connexin 43 on residue Tyr 265, resulting in a stable interaction between both proteins leading to inhibition of GAP junctional communication. In addition to tyrosine phosphorylation, connexin 43 has also been shown to be phosphorylated on serine in the absence of Src kinases and on both serine and tyrosine in cells expressing Src kinases such as pp60v-Src and/or c-Src.

Spezifität: P-Connexin 43 (S367) pAb detects endogenous levels of p-Connexin 43 protein.

Molekulargewicht: 43.0 kDa

Synonyme: CX43, GJAL, ODDD, DFNB38, Cx43, Npm1, Cnx43, Gja-1, AU042049, AW546267, Cx43alpha1, connexin43, Cx32, Cnx32, Gjb-1, MGC6217, AI118175, MGC93610, gja1, cx43a1, zfCx43.3, MGC128721, gja1-A, connexin 43, cx43, gjal, oddd, dfnb38, CONNEXIN 43

Anwendungen

Applikationshinweise: WB: 1:500-1:1000 IHC: 1:50-1:200

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE).

Reinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Gap Junction Protein, alpha 1, 43kd (GJA1) (pSer367) antibody

anti-Gap Junction Protein, alpha 1, 43kd (GJA1) (pSer367) antibody (Image 2)