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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Antikörper
| Antigen | C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) |
| Synonyme | ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272 |
| Klonalität | Polyklonal |
| Wirt |
Alternativen Kaninchen |
| Reaktivität |
Alternativen Human, Ratte (Rattus) |
| Applikation |
Alternativen Western Blot (WB), Immunhistochemie (IHC), Immunfluoreszenz (IF)
|
| Produktnummer | ABIN460546 |
| Menge | 100µg (1 mg/ml) (Varianten) |
| Preis | 572,09 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
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| Verfügbarkeit | Lieferung in 7 bis 10 Werktagen |
Produktbeschreibung
| Weitere Bezeichnung | c-Abl |
| Format | Liquid |
| Beschreibung |
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac. Synonyms: ABL1, ABL, C-ABL, EC 2.7.10.2, JTK7, P150, V-ABL |
| Spezifität | C-Abl (E883) pAb detects endogenous levels of c-Abl protein. |
| Molekulargewicht | 123 kDa |
Anwendungen
| Applikationshinweise | WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200 |
| Konzentration | 1 mg/ml |
| Reinheit | > 95% (by SDS-PAGE). |
| Reinigung | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Buffer | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
| Lagerung | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Bilder
| anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody (Image 2) |
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