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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Antikörper

Antigen

C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)

Synonyme ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen

Reaktivität
Alternativen

Human, Ratte (Rattus)

Applikation
Alternativen Western Blot (WB), Immunhistochemie (IHC), Immunfluoreszenz (IF)
Produktnummer ABIN460546
Menge 100µg  (1 mg/ml)  (Varianten)
Preis 572,09 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung

Weitere Bezeichnung c-Abl
Format Liquid
Beschreibung The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.
Synonyms: ABL1, ABL, C-ABL, EC 2.7.10.2, JTK7, P150, V-ABL
Spezifität C-Abl (E883) pAb detects endogenous levels of c-Abl protein.
Molekulargewicht 123 kDa

Anwendungen

Applikationshinweise WB: 1:500-1:1000 IHC: 1:50-1:200 IF: 1:50-1:200
Konzentration 1 mg/ml
Reinheit > 95% (by SDS-PAGE).
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Lagerung Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen

Alternativen zu Antigen "C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)", Typ "Antikörper" finden
Wirte Kaninchen (104), Maus (15)
Reaktivitäten Human (112), Maus (55), Ratte (Rattus) (34), Rind (Kuh) (16), Hund (15), Pferd (15), Schwein (15), Kaninchen (15), Affe (2)
Applikationen Western Blot (WB) (69), Immunhistochemie (Paraffinschnitte) (IHC (p)) (42), Immunhistochemie (IHC) (29), ELISA (26), Immunfluoreszenz (IF) (25), Enzyme Immunoassay (EIA) (19), Immunpräzipitation (IP) (17), Durchflusszytometrie (FACS) (13), Dot Blot (Dot) (8), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (2), Immunodiffusion (ID) (1), Immunoelectron Microscopy (IEM) (1), Neutralisierung (Neut) (1)
Konjugate Biotin (4), Alexa Flour 488 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
Epitope pTyr412 (13), Ab-412 (3), pTyr204 (3), pThr754 (2), pTyr251 (2), pTyr283 (2), C-Term (1), Center (1), N-Term H246 (1), N-Term K219 (1), Y251 (1), Y272 (1), Y276 (1), pSer588 (1), pTyr134 (1), pTyr245 (1), pTyr272 (1), pTyr276 (1), pY134 (1)