Paired-Like Homeodomain 1 (PITX1) Antikörper

Antigen: Paired-Like Homeodomain 1 (PITX1)

Synonyme: BFT, CCF, POTX, PTX1, Bft, Potx, Ptx1, P-OTX, PITX1, bft, potx, ptx1, xPitx1, MGC79589, X-PITX-1, MGC136976, zgc:136976

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus)

Applikation: Western Blot (WB), Immunhistochemie (IHC)

Produktnummer: ABIN460537

Produktbeschreibung

Weitere Bezeichnung: Pitx1

Format: Liquid

Beschreibung: Pitx1 and Pitx2 are highly homologous, bicoid-related transcription factors. Pitx1 is a bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary gland and first branchial arch. Deletion of the Pitx1 locus results in decreased distal expression of the hindlimb-specific marker, the T-box factor (Tbx4). Pitx1 may modulate morphogenesis, growth and patterning of a specific hindlimb region, and serves as a component of the variables that influence morphological and growth distinctions in forelimb and hindlimb identity. Pitx2 was initially identified as the gene responsible for human Rieger syndrome, an autosomal dominant condition that causes developmental abnormalities. Pitx2 is a transcription factor that regulates cardiac positioning and pituitary and tooth morphogenesis. Pitx2 also regulates lung symmetry by encoding “leftness” of the lung. Pitx2 is asymmetrically expressed in the left lateral-plate mesoderm, and mutant mice with laterality defects show altered patterns of Pitx2 expression that correlate with changes in the visceral symmetry. The genes which encode Pitx1 and Pitx2 map to human chromosomes 5q31 and 4q25-q26, respectively.
Synonyms: Hindlimb-expressed homeobox protein backfoot, PITX1, BFT. POTX. PTX1

Spezifität: Pitx1 (E130) pAb detects endogenous levels of Pitx1 protein.

Molekulargewicht: 34 kDa

Anwendungen

Applikationshinweise: WB: 1:500-1:1000 IHC: 1:50-1:200

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE).

Reinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Paired-Like Homeodomain 1 (PITX1) antibody

anti-Paired-Like Homeodomain 1 (PITX1) antibody (Image 2)