Janus Kinase 2 (JAK2) Antikörper

Antigen: Janus Kinase 2 (JAK2)

Synonyme: JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus)

Applikation: Western Blot (WB), Immunfluoreszenz (IF)

Produktnummer: ABIN460501

Produktbeschreibung

Weitere Bezeichnung: JAK2

Format: Liquid

Beschreibung: JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of cytokine receptors, JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin, it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes.
Synonyms: Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2

Spezifität: JAK2 (R564) pAb detects endogenous levels of JAK2 protein.

Molekulargewicht: 125 kDa

Anwendungen

Applikationshinweise: WB: 1:500-1:1000 IF: 1:50-1:200

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE).

Reinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Janus Kinase 2 (JAK2) antibody