X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Antikörper

Antigen: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4)

Synonyme: AW413319, AW545101, 2310057B22Rik, MGC95022, MGC73312, zgc:73312, MGC81443, XRCC4, MGC148661, DKFZp469B0634

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN459880

Produktbeschreibung

Weitere Bezeichnung: XRCC4

Format: Liquid

Beschreibung: The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
Synonyms: X-ray repair cross-complementing protein 4, XRCC4, 7518, XRCC4, 194363, Q13426,

Spezifität: XRCC4 (N291) pAb detects endogenous levels of XRCC4 protein.

Molekulargewicht: 40 kDa

Anwendungen

Applikationshinweise: WB: 1:500-1:1000

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE).

Reinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) antibody