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Chemokine (C-C Motif) Receptor 5 (CCR5) Antikörper

Antigen

Chemokine (C-C Motif) Receptor 5 (CCR5)

Synonyme CKR5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, FLJ78003, Ckr5, Cmkbr5, CCR5, CCR1-L, GPCR, MGC137803, CCR-5, AM4-7, CCR2, CCR5-L
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen

Reaktivität
Alternativen

Human

Applikation
Alternativen Western Blot (WB)
Produktnummer ABIN459775
Menge 100µg  (1 mg/ml)  (Varianten)
Preis 572,09 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung

Weitere Bezeichnung CCR5
Format Liquid
Beschreibung The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Synonyms: CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CHEMR13, CKR-5, CKR5, CMKBR5
Spezifität CCR5 (T343) pAb detects endogenous levels of CCR5 protein.
Molekulargewicht 50 kDa

Anwendungen

Applikationshinweise WB: 1:500-1:1000
Konzentration 1 mg/ml
Reinheit > 95% (by SDS-PAGE).
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Lagerung Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen

Alternativen zu Antigen "Chemokine (C-C Motif) Receptor 5 (CCR5)", Typ "Antikörper" finden
Wirte Ratte (58), Kaninchen (55), Maus (38), Hamster (24), Ziege (3)
Reaktivitäten Human (136), Maus (56), Ratte (Rattus) (23), Rind (Kuh) (2), Affe (2), Armenischer Hamster (1), Hund (1), Zebrafisch (Brachydanio rerio) (1)
Applikationen Durchflusszytometrie (FACS) (131), Western Blot (WB) (42), Immunfluoreszenz (IF) (40), Enzyme Immunoassay (EIA) (18), Immunhistochemie (Paraffinschnitte) (IHC (p)) (15), ELISA (12), ELISA (Detektionsantikörper) (9), Intrazelluläre Durchflusszytometrie (ICFC) (8), Immunpräzipitation (IP) (6), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (4), Immunhistochemie (IHC) (4), Funktionale Studien (Func) (3), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Dot Blot (Dot) (1), Immunzytochemie (ICC) (1), Immunoelectron Microscopy (IEM) (1), Neutralisierung (Neut) (1)
Konjugate PE (24), Biotin (17), FITC (11), Alexa Fluor 647 (5), Alexa Fluor 488 (3), APC (2), Alexa Fluor 700 (2), PerCP,Cy5.5 (2), RPE (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope pS349 (5), N-Term (3), pSer337 (3), pSer349 (3), pS337 (2), non pSer337/349 (1), non-pS337 (1)