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Antikörper
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anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Antikörper
BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Antikörper
| Antigen |
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| Synonyme |
BAM, BIM, BOD, BimL, BimEL, BIM-beta6, BIM-beta7, BIM-alpha6, Bim, Bod, 1500006F24Rik, bim |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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Western Blot (WB) (66), Immunfluoreszenz (IF) (25), Immunhistochemie (Paraffinschnitte) (IHC (p)) (24), Immunhistochemie (IHC) (15), Enzyme Immunoassay (EIA) (12), Durchflusszytometrie (FACS) (11), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), Immunpräzipitation (IP) (10), Immunzytochemie (ICC) (4), ELISA (3), Dot Blot (Dot) (1)
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| Produktnummer |
ABIN459425 |
| Menge |
100µg (1 mg/ml) (Varianten) |
| Preis |
572,09 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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Bim
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Format
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Liquid
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Beschreibung
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Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS or BimL, implying a unique role for BimEL in cell survival signaling.
Synonyms: Bcl2-interacting mediator of cell death, BIM, BIM
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Spezifität
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BIM-alpha/beta (A2) pAb detects endogenous levels of BIM-alpha/beta protein.
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Molekulargewicht
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25 kDa
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Applikationshinweise
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WB: 1:500-1:1000 IHC: 1:50-1:200
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Konzentration
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1 mg/ml
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Reinheit
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> 95% (by SDS-PAGE).
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Reinigung
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The pAb was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Buffer
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1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
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Lagerung
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11)", Typ "Antikörper" finden
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Wirte
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Kaninchen (62), Ziege (6), Hamster (6), Maus (6), Ratte (4)
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Reaktivitäten
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Human (75), Maus (59), Ratte (Rattus) (44), Affe (1)
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Applikationen
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Western Blot (WB) (66), Immunfluoreszenz (IF) (25), Immunhistochemie (Paraffinschnitte) (IHC (p)) (24), Immunhistochemie (IHC) (15), Enzyme Immunoassay (EIA) (12), Durchflusszytometrie (FACS) (11), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), Immunpräzipitation (IP) (10), Immunzytochemie (ICC) (4), ELISA (3), Dot Blot (Dot) (1)
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Konjugate
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Biotin (1)
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Epitope
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pSer69/65 (5), AA 2-198 (2), Center (2), N-Term (2), pSer69 (2), BH3 Domain (1), C-Term (1)
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Alternativen 
