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CD44 Antikörper

CD44 Reaktivität: Human, Maus, Hund, Pferd, Cat FACS, WB, IHC (p), IP, IHC (fro), ICC Wirt: Ratte Monoclonal IM7 unconjugated
Produktnummer ABIN457426
  • Target Alle CD44 Antikörper anzeigen
    CD44
    Reaktivität
    • 309
    • 169
    • 81
    • 30
    • 25
    • 23
    • 16
    • 11
    • 9
    • 9
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Hund, Pferd, Cat
    Wirt
    • 172
    • 123
    • 94
    • 2
    • 1
    Ratte
    Klonalität
    • 274
    • 116
    • 2
    Monoklonal
    Konjugat
    • 171
    • 44
    • 31
    • 27
    • 19
    • 9
    • 9
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD44 Antikörper ist unkonjugiert
    Applikation
    • 274
    • 156
    • 94
    • 77
    • 71
    • 71
    • 62
    • 40
    • 37
    • 31
    • 29
    • 13
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Spezifität
    The rat monoclonal antibody IM7 reacts with an extracellular epitope of CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.), it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.
    Kreuzreaktivität (Details)
    Human, Mouse, Canine (Dog), Equine (Horse), Feline (Cat)
    Aufreinigung
    Purified by protein-G affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
    Klon
    IM7
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product CD44 Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1 μg/mL, positive control: murine peripheral blood.
    Immunohistochemistry (paraffin sections): Positive tissue: murine spleen.
    Western blotting: Non-reducing conditions.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Hegde, Singh, Nagarkatti, Nagarkatti: "CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 134-42, (2008) (PubMed).

    Larkin, Renukaradhya, Sriram, Du, Gervay-Hague, Brutkiewicz: "CD44 differentially activates mouse NK T cells and conventional T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 268-79, (2006) (PubMed).

    van Royen, Voskuil, Hoefer, Jost, de Graaf, Hedwig, Andert, Wormhoudt, Hua, Hartmann, Bode, Buschmann, Schaper, van der Neut, Piek, Pals: "CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization." in: Circulation, Vol. 109, Issue 13, pp. 1647-52, (2004) (PubMed).

    Katoh, Matsumoto, Kawakita, Tominaga, Kincade, Matsukura: "A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia." in: The Journal of clinical investigation, Vol. 111, Issue 10, pp. 1563-70, (2003) (PubMed).

    Legg, Lewis, Parsons, Ng, Isacke: "A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility." in: Nature cell biology, Vol. 4, Issue 6, pp. 399-407, (2002) (PubMed).

    McKallip, Do, Fisher, Robertson, Nagarkatti, Nagarkatti: "Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens." in: International immunology, Vol. 14, Issue 9, pp. 1015-26, (2002) (PubMed).

    Xu, Manivannan, Liversidge, Sharp, Forrester, Crane: "Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier." in: Journal of leukocyte biology, Vol. 72, Issue 6, pp. 1133-41, (2002) (PubMed).

    Si-Tahar, Sitaraman, Shibahara, Madara: "Negative regulation of epithelium-neutrophil interactions via activation of CD44." in: American journal of physiology. Cell physiology, Vol. 280, Issue 3, pp. C423-32, (2001) (PubMed).

  • Target
    CD44
    Andere Bezeichnung
    CD44 (CD44 Produkte)
    Synonyme
    CDW44 antikoerper, CSPG8 antikoerper, ECMR-III antikoerper, HCELL antikoerper, HUTCH-I antikoerper, IN antikoerper, LHR antikoerper, MC56 antikoerper, MDU2 antikoerper, MDU3 antikoerper, MIC4 antikoerper, Pgp1 antikoerper, AU023126 antikoerper, AW121933 antikoerper, AW146109 antikoerper, HERMES antikoerper, Ly-24 antikoerper, Pgp-1 antikoerper, CD44A antikoerper, METAA antikoerper, RHAMM antikoerper, XCD44 antikoerper, cd44 antikoerper, cdw44 antikoerper, cspg8 antikoerper, ecmr-iii antikoerper, hcell antikoerper, lhr antikoerper, mc56 antikoerper, mdu2 antikoerper, mdu3 antikoerper, mic4 antikoerper, mutch-i antikoerper, pgp1 antikoerper, CD44 molecule (Indian blood group) antikoerper, syndecan 4 antikoerper, CD44 antigen antikoerper, CD44 molecule (Indian blood group) S homeolog antikoerper, CD44 antikoerper, SDC4 antikoerper, Cd44 antikoerper, cd44.S antikoerper
    Hintergrund
    CD44 Molecule,CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.,PGP-I, HUTCH-I, ECMR-III, Hermes antigen, Hyaluronate receptor, Heparan sulfate proteoglycan, Epican, MC56, MIC4
    Gen-ID
    12505
    UniProt
    P15379
    Pathways
    Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling
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