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ATF6 Antikörper (Middle Region)

ATF6 Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN453523
  • Target Alle ATF6 Antikörper anzeigen
    ATF6 (Activating Transcription Factor 6 (ATF6))
    Bindungsspezifität
    • 16
    • 15
    • 13
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 356-386, Middle Region
    Reaktivität
    • 84
    • 43
    • 33
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human
    Wirt
    • 72
    • 12
    • 1
    Kaninchen
    Klonalität
    • 74
    • 11
    Polyklonal
    Konjugat
    • 46
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser ATF6 Antikörper ist unkonjugiert
    Applikation
    • 76
    • 27
    • 27
    • 24
    • 17
    • 15
    • 15
    • 11
    • 7
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody recognizes ATF6.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity Chromatography on Protein A.
    Immunogen
    KLH conjugated synthetic peptide between 356~386 amino acids from the Center region of Human ATF6.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ATF6 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ATF6 (Activating Transcription Factor 6 (ATF6))
    Andere Bezeichnung
    ATF6 alpha (ATF6 Produkte)
    Synonyme
    ATF-6-like antikoerper, GB16435 antikoerper, ATF6 antikoerper, Atf6 antikoerper, ATF6A antikoerper, 9130025P16Rik antikoerper, 9630036G24 antikoerper, AA789574 antikoerper, Atf6alpha antikoerper, ESTM49 antikoerper, activating transcription factor 6 antikoerper, uncharacterized LOC412432 antikoerper, activating transcription factor 6 S homeolog antikoerper, cyclic AMP-dependent transcription factor ATF-6 alpha antikoerper, ATF6 antikoerper, LOC412432 antikoerper, atf6.S antikoerper, LOC100122162 antikoerper, Atf6 antikoerper
    Hintergrund
    ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. ATF6 could also be involved in activation of transcription by the serum response factor. ATF6 exists as a homodimer and heterodimer with ATF6 beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). It also interacts with the transcription factors GTF2I, YY1 and SRF. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. The basic domain of ATF6 functions as a nuclear localization signal and the basic leucine zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site 1 and site 2 proteases. ATF6 is N glycosylated, phosphorylated in vitro by MAPK14/P38MAPK and belongs to the bZIP family.Synonyms: ATF-6, Activating transcription factor 6 alpha, Cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha
    Gen-ID
    22926
    NCBI Accession
    NP_031374
    UniProt
    P18850
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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