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ASPSCR1 Antikörper (C-Term)

ASPSCR1 Reaktivität: Human WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN453522
  • Target Alle ASPSCR1 Antikörper anzeigen
    ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
    Bindungsspezifität
    • 15
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 52
    • 21
    • 15
    • 5
    • 4
    • 2
    • 1
    Human
    Wirt
    • 73
    • 7
    Kaninchen
    Klonalität
    • 73
    • 8
    Polyklonal
    Konjugat
    • 33
    • 8
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ASPSCR1 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 43
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody is specific to ASPSCR1/TUG (C-term).
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Protein A Chromatography followed by peptide affinity purification.
    Immunogen
    KLH conjugated synthetic peptide selected from the C-terminal region of Human ASPSCR1.
    Top Product
    Discover our top product ASPSCR1 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Western blot: 1/100approx. 1/500.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
    Andere Bezeichnung
    ASPSCR1 (ASPSCR1 Produkte)
    Synonyme
    tug antikoerper, aspl antikoerper, asps antikoerper, rcc17 antikoerper, ubxd9 antikoerper, aspcr1 antikoerper, ASPCR1 antikoerper, ASPL antikoerper, ASPS antikoerper, RCC17 antikoerper, TUG antikoerper, UBXD9 antikoerper, UBXN9 antikoerper, 1190006K01Rik antikoerper, ASPC antikoerper, ASPSCR1, UBX domain containing tether for SLC2A4 antikoerper, alveolar soft part sarcoma chromosome region, candidate 1 S homeolog antikoerper, alveolar soft part sarcoma chromosome region, candidate 1 antikoerper, alveolar soft part sarcoma chromosome region, candidate 1 (human) antikoerper, ASPSCR1 antikoerper, aspscr1.S antikoerper, Aspscr1 antikoerper, aspscr1 antikoerper, Bm1_55980 antikoerper
    Hintergrund
    ASPSCR1 is tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Insulin stimulates glucose uptake in fat and muscle by mobilizing the GLUT4 glucose transporter. GLUT4 is sequestered intracellularly in the absence of insulin, and is redistributed to the plasma membrane within minutes of insulin stimulation. Bogan et al. (2003) described a functional screen to identify proteins that modulate GLUT4 distribution, and identified TUG as a putative tether, containing a UBX domain, for GLUT4. They identified the ASPL protein as the probable human homolog of murine TUG. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4, in 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin. Distinct regions of TUG are required to bind GLUT4 and to retain GLUT4 intracellularly in transfected, nonadipose cells. Bogan et al. (2003) concluded that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether. Bogan et al. (2003) found that TUG exists in 2 isoforms, the longer of which contains a sequence at the amino terminus with similarity to ubiquitin that is predicted to be 550 residues long. The probable start codon in the short form is equivalent to methionine-78 of the long form.Synonyms: ASPL, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, RCC17, Renal papillary cell carcinoma protein 17, TUG, Tether containing UBX domain for GLUT4, UBX domain-containing protein 9, UBXD9, UBXN9
    Gen-ID
    79058
    NCBI Accession
    NP_076988
    UniProt
    Q9BZE9
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