3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antikörper

Antigen: 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN453103

Produktbeschreibung

Produktmerkmale: Synonyms: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Weitere Bezeichnung: HMG-CoA reductase / HMGCR

Gen-ID: 3156

Swiss-Prot: P04035

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human HMGCR

Kreuzreaktivität: Human

Beschreibung: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulatedvia a negative feedback mechanism mediated by sterols and non-sterol metabolitesderived from mevalonate, the product of the reaction catalyzed by reductase. Normally inmammalian cells this enzyme is suppressed by cholesterol derived from the internalizationand degradation of low density lipoprotein (LDL) via the LDL receptor. Competitiveinhibitors of the reductase induce the expression of LDL receptors in the liver, which in turnincreases the catabolism of plasma LDL and lowers the plasma concentration ofcholesterol, an important determinant of atherosclerosis.

Spezifität: This antibody detects HMGCR at Center. Species Reactivity: Tested: HumanAdd. Information: Molecular weight: 97476 Da

Anwendungen

Applikationshinweise: Western blot: 1: 50 - 1: 100. ELISA: 1: 1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 0.25 mg/ml

Buffer: PBS with 0.09% (W/V) sodium azide

Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar