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FOXE1 Antikörper (C-Term)

FOXE1 Reaktivität: Human IHC (p), EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN452689
  • Target Alle FOXE1 Antikörper anzeigen
    FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))
    Bindungsspezifität
    • 15
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 31
    • 24
    • 23
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 38
    • 1
    Ziege
    Klonalität
    • 39
    Polyklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FOXE1 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 16
    • 13
    • 13
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    Recognizes FOXE1 / TTF2 at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Bat, Elephant, Marmoset, Gorilla, Monkey, Rabbit.
    Species reactivity (tested):Human.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence C-AYPGGIDRFVSAM, from the C Terminus of the protein sequence according to NP_004464.2. Genename: FOXE1
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    Discover our top product FOXE1 Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Limit Dilution: 1/32000. Western blot: Preliminary experiments gave an approx 70 kDa band in Human Thymus andThyroid Gland lysates after 0.3 μg/mL antibody staining. Please note that currently wecannot find an explanation in the literature for the band we observe given the calculated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))
    Andere Bezeichnung
    FOXE1 / FKHL15 (FOXE1 Produkte)
    Synonyme
    FKHL15 antikoerper, FOXE2 antikoerper, HFKH4 antikoerper, HFKL5 antikoerper, TITF2 antikoerper, TTF-2 antikoerper, TTF2 antikoerper, Titf2 antikoerper, Ttf-2 antikoerper, Ci-FoxE antikoerper, Foxe1 antikoerper, FoxE5 antikoerper, ttf2 antikoerper, foxe2 antikoerper, hfkh4 antikoerper, hfkl5 antikoerper, titf2 antikoerper, ttf-2 antikoerper, fkhl15 antikoerper, foxE1 antikoerper, foxE antikoerper, forkhead box E1 antikoerper, foxE protein antikoerper, forkhead box E1 L homeolog antikoerper, FOXE1 antikoerper, Foxe1 antikoerper, foxE antikoerper, foxe1.L antikoerper, foxe1 antikoerper, foxE1 antikoerper
    Hintergrund
    Forkhead box protein E1 (FOXE1) is a member of the forkhead/ winged-helix domain transcription factor family. FOXE1, also designated FKHL15 or TTF-2, complexes with TTF-1 and Pax-8 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). FOXE1 encodes a protein that is expressed in several tissues, including thymus, adult brain, lung, liver, heart and pancreas. The chromosomal location of the FOXE1 gene on 9q22 suggests that it may be involved in squamous cell epithelioma and hereditary sensory neuropathy type I. Mutations in the FOXE1 gene lead to the development of congenital hypothyroidism, which occurs in approximately one in four thousand newborns and results in complete or partial failure of thyroid gland development. Patients who are homozygous for a missense mutation in the forkhead domain of he FOXE1 gene can also develop thyroid agenesis, cleft palate and choanal atresia. Subsequently, the FOXE1 gene may used as a marker to study these disorders.Synonyms: FOXE2, Forkhead box protein E1, HFKH4, HFKL5, HNF-3/fork head-like protein 5, TITF2, TTF-2, TTF2, Thyroid transcription factor 2
    Gen-ID
    2304
    NCBI Accession
    NP_004464
    UniProt
    O00358
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